The drug, called ELQ-300, wrecks the parasites’ ability to reproduce by disabling their mitochondria, the factories that produce two of the building blocks they need to make DNA. The drug does not harm human mitochondria, which produce energy rather than DNA.
ELQ-300 rapidly cured infected mice and killed parasites in mosquitoes that were allowed to feed on the mice shortly after infection, blocking further transmission to new victims.
Riscoe says that if ELQ-300 passes the obligatory safety tests, trials could begin in humans within two years.
…look at Singapore dengue cases since Jan 2013…. http://www.dengue.gov.sg, look at the chart , it showed dengue cases has up at least 4x based on the past 3 years records. Singapore is a very clean & beautiful small island with highly capable field inspectors, total 500 of them or more today. How come still not able to “clean” up all the wild breeding sites of Aedes spp? or there must be many “natural, hidden breeding sites in the wild” the no body could find! Also the the educational programme were all the while very active you can see so many perfect materials too on the website yet the community participation is far from satisfactorily, this observations are almost similar all over the world in the past 30 years. So could expect better results based on this same method education, community participation, spend 10 min a week to seek & destroy the breeding site since the last 30 years? Anyone looking outside the box at this moment???
Monroe County Health Department Administrator Bob Eadie said the report may leave people with the mistaken impression that the dengue risk remains.
In fact, there have been no other reported cases of dengue fever since October 2010, he said.
“We put a whole lot of effort into trying to eradicate the disease and it showed results,” Eadie said. “Unfortunately that kind of gets lost in the report.”
People infected during a recent outbreak in Florida didn’t catch the virus abroad but rather got a strain that’s unique to Key West, virologists at the Centers for Disease Control and Prevention report Wednesday in the journal Emerging Infectious Disease.
The virus has been circulating around the Key West population for at least two years, the researchers say, and it has evolved its own genetic fingerprint, distinct from dengue in Central America and the Caribbean.
“Today, Natalie Gulbis withdrew from this week’s RR Donnelley LPGA Founders Cup as she recovers from an illness that was confirmed to be Malaria. Natalie originally became ill in Singapore and she was treated and medically cleared to fly home,” the LPGA Tour and her management group IMG said in a statement.
“Natalie continues to be treated at home and is expected to be at full strength in three weeks.
Director Michael Doyle said roughly 100 people — 70 employees and 30 invited guests — are scheduled to be on hand for the summit that aims to make Mosquito Control a more efficient and environmentally friendly operation.
But don’t look to the program agenda for clues on what exactly will be discussed. It’s purposefully vague, Doyle said.
“They don’t want to tell people, ‘Here’s what we’re going to do.’ It’s more about what the employees and stakeholders find important, and take it from there,” he said.
Doyle said the idea came from a similar summit he attended last year for a private mosquito control company in Chicago. They spoke about green initiatives and efficiency improvements.
“I thought, ‘I wonder if that would work for us,” he said. “We have people stretched up and down the Keys and people moving a lot of places. People on the ground know better how time is spent and the little things that add up. A big part of this is going to be giving people the opportunity to talk about these kinds of things.”
Those scheduled to participate include Islamorada Vice Mayor Ted Blackburn, Marathon City Manager Roger Hernstadt, county commissioners David Rice and Heather Carruthers, Monroe County Health Department spokesman Christopher Tittel, Keys Energy Services spokesman Julio Barroso and School Board members Robin Smith-Martin and John Dick.
Doyle said they would be asked to provide outside perspectives on how the public feels about Mosquito Control. He said they’d help gauge the district’s “connection to the rest of the community.”
Impact of Indoor Residual Spraying of Lambdacyhalothrin on Malaria Prevalence and Anemia in an Epidemic-Prone District of Muleba, North-Western TanzaniaPosted: March 7, 2013
The Government of Tanzania introduced indoor residual spraying (IRS) in Muleba district in north-western Tanzania after frequent malaria epidemics. Malaria parasitological baseline and two cross-sectional follow-up surveys were conducted in villages under the IRS program and those not under IRS to assess the impact of IRS intervention. After two rounds of IRS intervention there was a significant reduction of malaria parasitological indices in both two villages. In IRS villages overall, parasitemia prevalence was reduced by 67.2%, splenomegaly was reduced by 75.8%, whereas anemia was reduced by 50.5%. There was also a decline of malaria parasite density from 896.4 at baseline to 128.8 at second follow-up survey. Similarly, there was also a reduction of malaria parasitological indices in non-IRS villages; however, parasitological indices in IRS villages remained far below the levels in non-IRS villages. The reduction of malaria parasitological indices in non-IRS villages might have been contributed to interventions other than IRS.