A New Malaria Compound. In the Pipeline:Posted: September 4, 2012
The best hope for the kinase-based inhibitors is that they’ll hit several malaria enzymes at once, which gives the organisms a bigger evolutionary barrier to jump over. The question is whether you can do that without hitting anything bad in the human kinome, but for the relatively short duration of acute malaria treatment, you should be able to get away with quite a bit. Throwing this compound and the existing antimalarials at the parasites simultaneously will really give them something to occupy themselves.
I’ll follow the development of this compound with interest. It’s just about to hit the really hard part of drug research – human beings in the clinic.