NOVAVAX, CPL Biologicals and the International Centre for Genetic Engineering and Biotechnology Announce Collaboration to Develop New Malaria Vaccine

The project  is being funded by  India’s Department of Biotechnology Vaccine Grand Challenge Program and will be managed by the Malaria Vaccine Development Program, a  New  Delhi-based not-for-profit  organization established to support the development of malaria vaccines. Novavax’s virus-like particle (VLP) vaccine  technology platform  will be applied to construct malaria  vaccine candidates, which CPLB will manufacture for advanced preclinical studies, clinical trials  and commercialization. The partners will  develop and evaluate VLPs that express Plasmodium falciparum circumsporozoite protein (PfCSP), which has been used to develop the only recombinant malaria vaccine that has shown efficacy in field trials.  After establishing  the  feasibility of Novavax’s technology, the partners will explore the possibility of producing additional VLPs against antigens from other stages of malaria parasites. The partners believe a multi-stage VLP malaria vaccine has the potential for higher efficacy compared to vaccines based on a single antigen or that target only one stage of the malaria parasite.

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