Medical News:%20Malaria Succumbs to Drug Combo – in Infectious Disease, General Infectious Disease from MedPage TodayPosted: April 5, 2012
Efficacy was lower but nearly identical in the two study arms on an intention-to-treat basis, the researchers indicated in the April 5 issue of the New England Journal of Medicine.
However, they also noted some geographic variation in time to response and in recrudescence rates that supported earlier suggestions of growing resistance to artemisinin-based drugs in Cambodia.
Pyronaridine is an existing anti-malarial drug that is mainly used in China, while artesunate and similar artemisinin-based agents are mainstays for malaria treatment in many endemic areas.
MMV, a public-private nonprofit partnership, believes that combining the two agents may be helpful in regions where artemisinin resistance in Plasmodium parasites is on the rise — at least until effective non-artemisinin drugs become available.