HIV & AIDS Information :: Lopinavir/ritonavir cuts malaria risk in children with HIV

Dr Achan concluded that children treated with LPV/r-based regimen had a significantly lower risk of getting malaria compared to children on an NNRTI-based regimen as a result of three potential mechanisms:

The pharmacokinetic effect of LPV/r on lumefantrine leading to a prolonged ‘post-treatment’ prophylactic effect after treatment with AL, and as such is the main driver of the outcome.

To a lesser extent the direct antimalarial effect of LPV/r; and

The potential antiparasitic synergy between LPV/r and lumefantrine.

These findings, she noted, suggest a role for ‘pharmaco-enhancement’ as a tool to help reduce the burden of malaria in high endemic settings among HIV-infected individuals.

via HIV & AIDS Information :: Lopinavir/ritonavir cuts malaria risk in children with HIV.

Advertisements


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s