Novartis and collaborators discover new dual-acting class of antimalarial compounds with potential to both prevent and treat malaria infections

Basel, November 17, 2011 – The discovery of a new class of dual-acting antimalarial compounds – the imidazolopiperazines IZPs – was published in the journal Science online, at the Science Express website today[1]. The findings report on compounds that target both liver and blood infections, attacking the Plasmodium parasite at both stages in its reproduction cycle.The findings describe how scientists developed a novel assay to determine liver stage activity of candidate small molecules, then used the assay and other tools to identify and optimize a chemical scaffold with activity on both blood- and liver-stage parasites in malaria mouse models. Several other compound classes, also with dual activity, are described and released by Novartis through ChEMBL – Neglected Tropical Disease at https://www.ebi.ac.uk/chemblntd.

via Novartis and collaborators discover new dual-acting class of antimalarial compounds with potential to both prevent and treat malaria infections.

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